1,647 research outputs found
S100B in Guillain-Barre syndrome.
BR J ANAESTH. 2006 JAN;96(1):141-2
Histogram analysis of magnetic resonance images: evaluation of intra-tumoral heterogeneity and correlation with pathological findings in solid pancreatic tumors.
Objectives To evaluate magnetic resonance (MR)-derived whole-tumor histogram analysis parameters in predicting aggressiveness of pancreatic ductal adenocarcinomas (PDACs) and neuroendocrine neoplasms (panNENs). Methods Pre-operative MR of 169 consecutive patients with PDAC or panNEN were retrospectively analyzed. T1-/T2-weighted images and apparent diffusion coefficient (ADC) maps were analyzed. Histogram-derived parameters were compared to several pathological features (grade, vascular infiltration, nodal and hepatic metastases) using Mann-Whitney U test. Diagnostic accuracy was assessed by receiver operating characteristic area under curve (ROC-AUC) analysis; sensitivity and specificity were assessed for each histogram parameter. Results No significant differences were found among histogram parameters for prediction of PDACs grade. ADCentropy was significantly higher in G2-3 panNENs with ROC-AUC 0.757; sensitivity was 83.3%. ADCentropy was significantly higher in PDACs with vascular involvement (p=.022; AUC=.641), with specificity of 92.2%. ADCskewness was significantly higher in PDACs with nodal metastases (p=.027; AUC=.642), with 72% specificity. ADCkurtosis was higher in panNENs with vascular involvement, nodal and hepatic metastases (p= .008, .021, and .008; ROC-AUC= 0.820, 0.709, and 0.820); sensitivity and specificity were: 85.7/74.3%; 36.8/96.5%; and 100/62.8%. No significant differences between groups were found for other histogram-derived parameters (p >.05). Conclusions Whole-tumors histogram analysis of ADC values is a valuable tool for predicting aggressiveness of PDACs and panNENs. Our results indicate that histogram metrics related to intra-tumor heterogeneity, as ADCentropy, ADCkurtosis and ADCskewness are the most accurate parameters for the identification of PDACs and panNENs with higher biological aggressiveness. Further and larger studies are needed to incorporate the results of the histogram analysis within decision support models and to mine these data to detect possible correlations with genomic patterns
The Extinction and Distance of Maffei 1
We have obtained low- and high-resolution spectra of the core of the
highly-reddened elliptical galaxy Maffei 1. From these data, we have obtained
the first measurement of the Mg2 index, and have measured the velocity
dispersion and radial velocity with improved accuracy. To evaluate the
extinction, a correlation between the Mg2 index and effective V-I colour has
been established for elliptical galaxies. Using a new method for correcting for
effective wavelength shifts, we find A_V = 4.67 +/- 0.19 mag, which is lower by
0.4 mag than previously thought. To establish the distance, the Fundamental
Plane for elliptical galaxies has been constructed in I. The velocity
dispersion of Maffei 1, measured to be 186.8 +/- 7.4 km/s, in combination with
modern wide-field photometry in I, leads to a distance of 2.92 +/- 0.37 Mpc.
The Dn-sigma relation, which is independently calibrated, gives 3.08 +/- 0.85
Mpc and 3.23 +/- 0.67 Mpc from photometry in B and K`, respectively. The
weighted mean of the three estimates is 3.01 +/- 0.30 Mpc. The distance and
luminosity make Maffei 1 the nearest giant elliptical galaxy. The radial
velocity of Maffei 1 is +66.4 +/- 5.0 km/s, significantly higher than the
accepted value of -10 km/s. The Hubble distance corresponding to the mean
velocity of Maffei 1, Maffei 2 and IC342 is 3.5 Mpc. Thus, it is unlikely that
Maffei 1 has had any influence on Local Group dynamics
Status of the Cylindical-GEM project for the KLOE-2 Inner Tracker
The status of the R&D on the Cylindrical-GEM (CGEM) detector foreseen as
Inner Tracker for KLOE-2, the upgrade of the KLOE experiment at the DAFNE
phi-factory, will be presented. The R&D includes several activities: i) the
construction and complete characterization of the full-size CGEM prototype,
equipped with 650 microns pitch 1-D longitudinal strips; ii) the study of the
2-D readout with XV patterned strips and operation in magnetic field (up to
1.5T), performed with small planar prototypes in a dedicated test at the H4-SPS
beam facility; iii) the characterization of the single-mask GEM technology for
the realization of large-area GEM foils.Comment: 4 pages, 10 figures, Presented at Vienna Conference on
Instrumentation (Feb 15-20, 2010, Vienna, Austria). Submitted to the
Proceeding
Carbon in Spiral Galaxies from Hubble Space Telescope Spectroscopy
We present measurements of the gas-phase C/O abundance ratio in six H II
regions in the spiral galaxies M101 and NGC 2403, based on ultraviolet
spectroscopy using the Faint Object Spectrograph on the Hubble Space Telescope.
The C/O ratios increase systematically with O/H in both galaxies, from log C/O
approximately -0.8 at log O/H = -4.0 to log C/O approx. -0.1 at log O/H = -3.4.
C/N shows no correlation with O/H. The rate of increase of C/O is somewhat
uncertain because of uncertainty as to the appropriate UV reddening law, and
uncertainty in the metallicity dependence on grain depletions. However, the
trend of increasing C/O with O/H is clear, confirming and extending the trend
in C/O indicated previously from observations of irregular galaxies. Our data
indicate that the radial gradients in C/H across spiral galaxies are steeper
than the gradients in O/H. Comparing the data to chemical evolution models for
spiral galaxies shows that models in which the massive star yields do not vary
with metallicity predict radial C/O gradients that are much flatter than the
observed gradients. The most likely hypothesis at present is that stellar winds
in massive stars have an important effect on the yields and thus on the
evolution of carbon and oxygen abundances. C/O and N/O abundance ratios in the
outer disks of spirals determined to date are very similar to those in dwarf
irregular galaxies. This implies that the outer disks of spirals have average
stellar population ages much younger than the inner disks.Comment: 38 pages, 9 postscript figures, uses aaspp4.sty. Accepted for
publication in The Astrophysical Journa
The physical parameters, excitation and chemistry of the rim, jets and knots of the planetary nebula NGC 7009
We present long-slit optical spectra along the major axis of the planetary
nebula NGC 7009. These data allow us to discuss the physical, excitation and
chemical properties of all the morphological components of the nebula,
including its remarkable systems of knots and jets. The main results of this
analysis are the following: i) the electron temperature throughout the nebula
is remarkably constant, T_e[OIII] = 10200K; ii) the bright inner rim and inner
pair of knots have similar densities of N_e = 6000cm^{-3}, whereas a much lower
density of N_e = 1500cm^{-3} is derived for the outer knots as well as for the
jets; iii) all the regions (rim, inner knots, jets and outer knots) are mainly
radiatively excited; and iv) there are no clear abundance changes across the
nebula for He, O, Ne, or S. There is a marginal evidence for an overabundance
of nitrogen in the outer knots (ansae), but the inner ones (caps) and the rim
have similar N/H values that are at variance with previous results. Our data
are compared to the predictions of theoretical models, from which we conclude
that the knots at the head of the jets are not matter accumulated during the
jet expansion through the circumstellar medium, neither can their origin be
explained by the proposed HD or MHD interacting-wind models for the formation
of jets/ansae, since the densities as well as the main excitation mechanisms of
the knots, disagree with model predictions.Comment: Figure 1 was changed because features were misidentified in the
previous version. 17 pages including 5 figures and 3 tables. ApJ in press.
Also available at http://www.iac.es/galeria/denise
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